HHLA2

Across TCGA patient cohorts, HHLA2 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HHLA2-associated genes across cancer lineages are Cyclin-B1, eEF2, and INPP4B. Each is linked with HHLA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HHLA2-to-partner and partner-to-HHLA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by HHLA2-low versus HHLA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HHLA2→partner) and Y-score (partner→HHLA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.625	+2.700	.001	.006	3	3
SKCM	eEF2 →	+0.269	+2.824	.047	.034	3	2
COAD	INPP4B →	-0.461	-2.991	.017	.036	3	2
COAD	ATM →	-0.758	-3.000	<.001	.034	3	2
UCEC	MEK1 →	+0.374	+2.415	.004	.003	3	2
UCEC	PCNA →	+0.154	+1.700	.047	.042	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Cyclin-B1 by HHLA2 expression — UCEC

Explore this box plot interactively →