HHLA2

Across TCGA cell cohorts, HHLA2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,402 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HHLA2-associated GO terms across cancer lineages are Equilibrioception, Negative regulation of granulocyte chemotaxis, and Cellular response to rapamycin. Each is linked with HHLA2 in more than 4 cancer types. Because this analysis shows association rather than direction, both HHLA2-to-partner and partner-to-HHLA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Equilibrioception grouped by HHLA2-low versus HHLA2-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HHLA2→partner) and Y-score (partner→HHLA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Equilibrioception →	+1.504	+2.063	<.001	<.001	3	5
LARGE_INTESTINE	Negative regulation of granulocyte chemotaxis →	+1.235	+1.892	<.001	<.001	3	5
STOMACH	Cellular response to rapamycin →	-0.139	-1.384	<.001	.001	3	5
LARGE_INTESTINE	Negative regulation of neutrophil chemotaxis →	+1.235	+1.892	<.001	<.001	3	5
PANCREAS	Cold acclimation →	+0.183	+1.503	.002	.003	3	5
BLOOD_Lymphoma	Mature conventional dendritic cell differentiation →	+1.077	+1.366	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,402 associations by consensus.

Equilibrioception by HHLA2 expression — LARGE_INTESTINE

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