HHLA2

Across TCGA cell cohorts, HHLA2 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HHLA2-associated genes across cancer lineages are LYZL4, OR4K2, and BPIFB6. Each is linked with HHLA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HHLA2-to-partner and partner-to-HHLA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYZL4 grouped by HHLA2-low versus HHLA2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HHLA2→partner) and Y-score (partner→HHLA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LYZL4 →	+0.049	+4.152	.005	.009	3	1
BLOOD_Leukemia	OR4K2 →	+0.031	+4.969	<.001	.003	3	1
BLOOD_Leukemia	BPIFB6 →	+0.047	+4.969	<.001	.003	3	1
BLOOD_Leukemia	MOS →	+0.068	+4.705	<.001	.003	3	1
BLOOD_Leukemia	DRD1 →	+0.006	+5.060	<.001	.001	3	1
BLOOD_Leukemia	BPIFB3 →	+0.161	+4.874	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

LYZL4 by HHLA2 expression — BLOOD_Leukemia

Explore this box plot interactively →