HHIPL2

Across TCGA patient cohorts, HHIPL2 mutation is significantly associated with the RNA expression of many other genes, with 3,420 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HHIPL2-associated genes across cancer lineages are RNU1-68P, CDC45, and LINC02378. Each is linked with HHIPL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HHIPL2-to-partner and partner-to-HHIPL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-68P grouped by HHIPL2-low versus HHIPL2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HHIPL2→partner) and Y-score (partner→HHIPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU1-68P →	+0.086	+3.870	<.001	.009	3	3
LUAD	CDC45 →	+1.064	+2.999	<.001	.001	3	3
LUAD	LINC02378 →	+0.123	+2.056	<.001	.005	3	3
BRCA	LINC01072 →	+0.186	+3.726	<.001	.005	3	3
UCEC	ABHD3 →	+0.559	+1.794	<.001	<.001	3	3
BLCA	MON1A →	+0.547	+3.202	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,420 associations by consensus.

RNU1-68P by HHIPL2 expression — BLCA

Explore this box plot interactively →