HHIPL2

Across TCGA patient cohorts, HHIPL2 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HHIPL2-associated genes across cancer lineages are GAPDH, Bim, and EGFR_pY1068. Each is linked with HHIPL2 in more than 3 cancer types. Because this analysis shows association rather than direction, both HHIPL2-to-partner and partner-to-HHIPL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by HHIPL2-low versus HHIPL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HHIPL2→partner) and Y-score (partner→HHIPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.449	+2.169	.007	.003	3	4
LUAD	Bim →	+0.380	+3.321	.003	.009	3	2
UCEC	EGFR_pY1068 →	-0.170	-2.087	.031	.005	3	2
UCEC	eIF4E →	+0.151	+1.887	.022	.029	3	2
UCEC	Lck →	+0.285	+1.584	<.001	.005	3	2
UCEC	MEK1 →	+0.437	+2.115	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

GAPDH by HHIPL2 expression — UCEC

Explore this box plot interactively →