HHIPL2

Across TCGA cell cohorts, HHIPL2 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HHIPL2-associated genes across cancer lineages are ARMS2, CCDC60, and SPATA19. Each is linked with HHIPL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HHIPL2-to-partner and partner-to-HHIPL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARMS2 grouped by HHIPL2-low versus HHIPL2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HHIPL2→partner) and Y-score (partner→HHIPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ARMS2 →	+0.131	+3.415	<.001	.009	3	2
OVARY	CCDC60 →	+0.037	+3.058	.003	.004	3	2
PANCREAS	SPATA19 →	+0.047	+4.614	<.001	.004	3	1
PANCREAS	COX7B2 →	+1.093	+4.011	<.001	.009	3	1
PANCREAS	HBG1 →	+0.088	+4.786	<.001	.001	3	1
PANCREAS	KLF18 →	+0.011	+4.011	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

ARMS2 by HHIPL2 expression — LUNG_SCLC

Explore this box plot interactively →