HHIPL1

Across TCGA patient cohorts, HHIPL1 mutation is significantly associated with the RNA expression of many other genes, with 1,524 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HHIPL1-associated genes across cancer lineages are PCMTD1P1, RNU6-1197P, and ABHD3. Each is linked with HHIPL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HHIPL1-to-partner and partner-to-HHIPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCMTD1P1 grouped by HHIPL1-low versus HHIPL1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HHIPL1→partner) and Y-score (partner→HHIPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	PCMTD1P1 →	+0.077	+4.289	<.001	.007	3	3
HNSC	RNU6-1197P →	+0.400	+5.736	<.001	.003	3	2
UCEC	ABHD3 →	+0.497	+2.010	.004	<.001	3	2
UCEC	CD3G →	+0.430	+2.321	.006	<.001	3	2
UCEC	MFSD12 →	+0.360	+1.748	.006	.002	3	2
UCEC	RBM15 →	+0.316	+2.010	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,524 associations by consensus.

PCMTD1P1 by HHIPL1 expression — BLCA

Explore this box plot interactively →