HHIPL1

Across TCGA patient cohorts, HHIPL1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HHIPL1-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and 14-3-3_beta. Each is linked with HHIPL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HHIPL1-to-partner and partner-to-HHIPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by HHIPL1-low versus HHIPL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HHIPL1→partner) and Y-score (partner→HHIPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.247	+2.029	.008	.017	3	3
UCEC	Cyclin-B1 →	+0.593	+3.807	.002	<.001	3	2
UCEC	14-3-3_beta →	-0.072	-1.847	.040	.049	3	1
UCEC	eEF2 →	+0.363	+1.440	.003	.024	3	1
UCEC	EGFR_pY1068 →	-0.199	-1.584	.022	.034	3	1
UCEC	ERK2 →	+0.299	+3.000	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

4E-BP1 by HHIPL1 expression — UCEC

Explore this box plot interactively →