HHIPL1

Across TCGA cell cohorts, HHIPL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,595 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible HHIPL1-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Negative regulation of myoblast fusion, and Endoplasmic reticulum to Golgi vesicle-mediated transport. Each is linked with HHIPL1 in more than 12 cancer types. Because this analysis shows association rather than direction, both HHIPL1-to-partner and partner-to-HHIPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by HHIPL1-low versus HHIPL1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HHIPL1→partner) and Y-score (partner→HHIPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of syncytium formation by plasma membrane fusion →	+0.110	+0.436	<.001	<.001	3	13
OVARY	Negative regulation of myoblast fusion →	+0.115	+0.436	<.001	<.001	3	11
SKIN	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.053	+0.168	<.001	<.001	3	11
LUNG_SCLC	Protein folding →	+0.081	+0.508	<.001	.007	3	10
LUNG_NSCLC_LUAD	Protein localization to vacuole →	+0.064	+0.557	<.001	<.001	3	10
LUNG_NSCLC_LUAD	Cellular response to starvation →	+0.030	+0.353	.007	.003	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,595 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by HHIPL1 expression — OVARY

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