HHIPL1

Across TCGA cell cohorts, HHIPL1 mutation is significantly associated with the RNA expression of many other genes, with 320 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HHIPL1-associated genes across cancer lineages are FTHL17, ZNF48, and DEPDC1. Each is linked with HHIPL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HHIPL1-to-partner and partner-to-HHIPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FTHL17 grouped by HHIPL1-low versus HHIPL1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HHIPL1→partner) and Y-score (partner→HHIPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	FTHL17 →	+0.022	+4.222	<.001	.006	3	2
LARGE_INTESTINE	ZNF48 →	+0.559	+3.212	.004	.006	3	2
LARGE_INTESTINE	DEPDC1 →	+0.816	+3.212	.003	.006	3	2
OVARY	BMP15 →	+0.074	+4.222	<.001	.006	3	1
OVARY	PDHA2 →	+0.004	+4.222	<.001	.006	3	1
OVARY	OR8J3 →	+0.016	+4.222	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 320 associations by consensus.

FTHL17 by HHIPL1 expression — OVARY

Explore this box plot interactively →