HHEX

Across TCGA patient cohorts, HHEX protein abundance is significantly associated with the RNA expression of many other genes, with 243 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HHEX-associated genes across cancer lineages are SRD5A1, GALNT16, and NFATC2. Each is linked with HHEX in more than 1 cancer types. Because this analysis shows association rather than direction, both HHEX-to-partner and partner-to-HHEX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HHEX versus SRD5A1 in LSCC, with a Pearson correlation of -0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HHEX→partner) and Y-score (partner→HHEX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SRD5A1 →	-1.155	-0.468	.001	.007	3	2
PDAC	GALNT16 →	+0.911	+0.564	<.001	.001	3	1
PDAC	NFATC2 →	+0.953	+0.392	<.001	.002	3	1
PDAC	BMX →	+1.190	+0.537	<.001	.003	3	1
PDAC	MYEF2 →	+0.982	+0.456	<.001	<.001	3	1
PDAC	VIPR2 →	+0.815	+0.595	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 243 associations by consensus.

HHEX vs SRD5A1 — LSCC

Explore this scatter interactively →