HHEX

Across TCGA patient cohorts, HHEX mutation is significantly associated with the RNA expression of many other genes, with 375 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HHEX-associated genes across cancer lineages are ACTRT2, GPX6, and TMEM225. Each is linked with HHEX in more than 1 cancer types. Because this analysis shows association rather than direction, both HHEX-to-partner and partner-to-HHEX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACTRT2 grouped by HHEX-low versus HHEX-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HHEX→partner) and Y-score (partner→HHEX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	ACTRT2 →	+0.102	+6.257	<.001	.001	3	1
READ	GPX6 →	+0.044	+5.653	<.001	.003	3	1
READ	TMEM225 →	+0.114	+5.039	<.001	.008	3	1
READ	IGHD5-12 →	+1.742	+5.421	<.001	.005	3	1
READ	MED28P4 →	+0.394	+5.039	<.001	.008	3	1
READ	APOOP2 →	+0.655	+5.039	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 375 associations by consensus.

ACTRT2 by HHEX expression — READ

Explore this box plot interactively →