HHEX

Across TCGA patient cohorts, HHEX mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HHEX-associated genes across cancer lineages are EGFR_pY1068, ACC1, and Heregulin. Each is linked with HHEX in more than 1 cancer types. Because this analysis shows association rather than direction, both HHEX-to-partner and partner-to-HHEX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by HHEX-low versus HHEX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HHEX→partner) and Y-score (partner→HHEX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.359	-2.459	.003	.020	3	1
UCEC	ACC1 →	+0.410	+2.820	.019	.035	3	1
UCEC	Heregulin →	-0.140	-2.459	.019	.020	3	1
UCEC	INPP4B →	-0.431	-3.169	.005	.018	3	1
UCEC	MEK1 →	+0.381	+2.459	.031	.020	3	1
UCEC	Myosin-IIa →	+0.240	+2.466	.007	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

EGFR_pY1068 by HHEX expression — UCEC

Explore this box plot interactively →