HHEX

Across TCGA cell cohorts, HHEX RNA expression is significantly associated with the go_rna of many other GO terms, with 4,123 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HHEX-associated GO terms across cancer lineages are Negative regulation of cytoplasmic translational initiation, Protein-DNA complex assembly, and Regulation of mRNA export from nucleus. Each is linked with HHEX in more than 13 cancer types. Because this analysis shows association rather than direction, both HHEX-to-partner and partner-to-HHEX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cytoplasmic translational initiation grouped by HHEX-low versus HHEX-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HHEX→partner) and Y-score (partner→HHEX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of cytoplasmic translational initiation →	-0.119	-1.675	<.001	<.001	3	14
LARGE_INTESTINE	Protein-DNA complex assembly →	+0.048	+1.317	.002	.002	3	8
URINARY_TRACT	Regulation of mRNA export from nucleus →	-0.154	-2.861	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	'de novo' AMP biosynthetic process →	+0.110	+0.856	.001	<.001	3	8
CNS	Mitochondrial gene expression →	+0.067	+1.263	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA replication →	+0.077	+1.220	.002	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,123 associations by consensus.

Negative regulation of cytoplasmic translational initiation by HHEX expression — BONE

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