HHEX

Across TCGA cell cohorts, HHEX mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HHEX-associated genes across cancer lineages are OR2F2, OR13C7, and OPRM1. Each is linked with HHEX in more than 1 cancer types. Because this analysis shows association rather than direction, both HHEX-to-partner and partner-to-HHEX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2F2 grouped by HHEX-low versus HHEX-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HHEX→partner) and Y-score (partner→HHEX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR2F2 →	+0.036	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR13C7 →	+0.049	+6.266	<.001	<.001	3	1
BLOOD_Leukemia	OPRM1 →	+0.012	+5.201	.003	.006	3	1
BLOOD_Leukemia	TPPP2 →	+0.044	+5.201	<.001	.006	3	1
LARGE_INTESTINE	COX6A2 →	+0.082	+4.437	<.001	.004	3	1
LARGE_INTESTINE	TRDN →	+0.036	+4.054	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR2F2 by HHEX expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →