HHATL

Across TCGA patient cohorts, HHATL mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HHATL-associated genes across cancer lineages are Annexin-1, STAT3_pY705, and EGFR_pY1068. Each is linked with HHATL in more than 1 cancer types. Because this analysis shows association rather than direction, both HHATL-to-partner and partner-to-HHATL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by HHATL-low versus HHATL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HHATL→partner) and Y-score (partner→HHATL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.456	+1.604	.018	.041	3	2
SKCM	STAT3_pY705 →	-0.315	-2.459	.015	.020	3	2
UCEC	EGFR_pY1068 →	-0.301	-2.247	.001	.001	3	1
UCEC	A-Raf_pS299 →	-0.106	-1.847	.015	.008	3	1
UCEC	ERK2 →	+0.158	+1.847	.025	.008	3	1
UCEC	JNK_pT183_Y185 →	-0.198	-2.234	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Annexin-1 by HHATL expression — UCEC

Explore this box plot interactively →