HHATL

Across TCGA cell cohorts, HHATL mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible HHATL-associated genes across cancer lineages are IFNA4, VAX2, and EIF1. Each is linked with HHATL in more than 1 cancer types. Because this analysis shows association rather than direction, both HHATL-to-partner and partner-to-HHATL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA4 grouped by HHATL-low versus HHATL-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HHATL→partner) and Y-score (partner→HHATL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IFNA4 →	+0.024	+4.922	.009	.009	3	1
SKIN	VAX2 →	-0.744	-3.169	.001	.009	3	1
SKIN	EIF1 →	+0.438	+3.212	.006	.006	3	1
SKIN	OR6K6 →	+0.012	+3.192	<.001	.002	3	1
SKIN	C1S →	-2.070	-3.169	.002	.009	3	1
SKIN	MEI4 →	+0.131	+2.932	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

IFNA4 by HHATL expression — BLOOD_Leukemia

Explore this box plot interactively →