HGSNAT

Across TCGA pan-cancer cohorts, HGSNAT mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HGSNAT data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HGSNAT mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HGSNAT expression acts as an unfavorable survival marker.

UCEC, GBM, and CCRCC are the cancer types where HGSNAT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.743	0.959	.004	68	view →
GBM	DFS	Tertile	All	0.617	0.897	<.001	21	view →
CCRCC	DFS	Median	IV	0.227	0.932	.002	18	view →
HNSC	OS	Tertile	IV	0.705	0.974	.045	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HGSNAT–UCEC (DFS)

Open the UCEC breakdown →