HGSNAT

Across TCGA patient cohorts, HGSNAT mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HGSNAT-associated genes across cancer lineages are FoxM1, TFRC, and ATM. Each is linked with HGSNAT in more than 1 cancer types. Because this analysis shows association rather than direction, both HGSNAT-to-partner and partner-to-HGSNAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by HGSNAT-low versus HGSNAT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HGSNAT→partner) and Y-score (partner→HGSNAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.201	+1.710	.030	.025	3	2
UCEC	TFRC →	+0.618	+3.459	.001	.005	3	2
UCEC	ATM →	-0.765	-3.986	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.089	-1.847	.014	.049	3	1
UCEC	EGFR_pY1068 →	-0.272	-2.321	.002	.005	3	1
UCEC	eIF4E →	+0.213	+2.321	.004	.001	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

FoxM1 by HGSNAT expression — UCEC

Explore this box plot interactively →