HGSNAT

Across TCGA cell cohorts, HGSNAT mutation is significantly associated with the RNA expression of many other genes, with 520 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HGSNAT-associated genes across cancer lineages are OPRPN, PRAMEF9, and PRAMEF7. Each is linked with HGSNAT in more than 1 cancer types. Because this analysis shows association rather than direction, both HGSNAT-to-partner and partner-to-HGSNAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPRPN grouped by HGSNAT-low versus HGSNAT-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HGSNAT→partner) and Y-score (partner→HGSNAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OPRPN →	+0.045	+4.087	<.001	.009	3	1
URINARY_TRACT	PRAMEF9 →	+0.010	+4.087	<.001	.009	3	1
BLOOD_Leukemia	PRAMEF7 →	+0.009	+4.539	.008	.007	3	1
LARGE_INTESTINE	JOSD1 →	+0.547	+3.169	.003	.006	3	1
LARGE_INTESTINE	MIOX →	+0.294	+3.502	<.001	.001	3	1
LARGE_INTESTINE	RPL3 →	+0.593	+3.389	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 520 associations by consensus.

OPRPN by HGSNAT expression — URINARY_TRACT

Explore this box plot interactively →