Across TCGA patient cohorts, HGS RNA expression is significantly associated with the protein abundance of many other proteins, with 11,729 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HGS-associated proteins across cancer lineages are EIF4A3, RPTOR, and UTP15. Each is linked with HGS in more than 4 cancer types. Because this analysis shows association rather than direction, both HGS-to-partner and partner-to-HGS results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HGS→partner) and Y-score (partner→HGS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	EIF4A3 →	+0.224	+0.421	<.001	<.001	3	5
COAD	RPTOR →	+0.234	+0.548	.001	<.001	3	5
LSCC	UTP15 →	+0.289	+0.481	<.001	<.001	3	5
LSCC	CHERP →	+0.181	+0.287	<.001	<.001	3	4
LSCC	COIL →	+0.377	+0.451	<.001	<.001	3	4
LUAD	MCM2_S41 →	+0.722	+0.444	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,729 associations by consensus.

Exploration

HGS survival (RNA) · tumor vs normal (RNA) · all HGS data types