Across TCGA patient cohorts, HGS protein abundance is significantly associated with the RNA expression of many other genes, with 9,186 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HGS-associated genes across cancer lineages are SERINC1, ARHGAP12, and NBEA. Each is linked with HGS in more than 3 cancer types. Because this analysis shows association rather than direction, both HGS-to-partner and partner-to-HGS results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HGS→partner) and Y-score (partner→HGS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SERINC1 →	+0.609	+0.174	<.001	<.001	3	4
UCEC	ARHGAP12 →	+0.562	+0.162	<.001	<.001	3	4
UCEC	NBEA →	+1.004	+0.148	<.001	.001	3	4
UCEC	ZNF25 →	+0.770	+0.194	<.001	<.001	3	4
BRCA	CAB39L →	+0.638	+0.147	.005	.001	3	3
GBM	ACBD5 →	+0.404	+0.185	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,186 associations by consensus.

Exploration

HGS survival (RNA) · tumor vs normal (RNA) · all HGS data types