Across TCGA cell cohorts, HGS RNA expression is significantly associated with the go_rna of many other GO terms, with 3,819 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible HGS-associated GO terms across cancer lineages are Regulation of transcription of nucleolar large rRNA by RNA polymerase I, Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, and Positive regulation of synaptic plasticity. Each is linked with HGS in more than 17 cancer types. Because this analysis shows association rather than direction, both HGS-to-partner and partner-to-HGS results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HGS→partner) and Y-score (partner→HGS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.160	+0.823	<.001	<.001	3	18
BONE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.163	+0.661	<.001	<.001	3	15
BONE	Positive regulation of synaptic plasticity →	+0.157	+0.687	<.001	<.001	3	14
SKIN	Protein depolymerization →	+0.125	+0.796	<.001	<.001	3	13
BREAST	mRNA cis splicing, via spliceosome →	+0.074	+0.787	<.001	<.001	3	12
CNS	U2-type prespliceosome assembly →	+0.072	+0.527	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,819 associations by consensus.

Exploration

HGS survival (RNA) · tumor vs normal (RNA) · all HGS data types