Across TCGA cell cohorts, HGS mutation is significantly associated with the RNA expression of many other genes, with 216 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HGS-associated genes across cancer lineages are HIPK4, LYSMD1, and BORCS6. Each is linked with HGS in more than 1 cancer types. Because this analysis shows association rather than direction, both HGS-to-partner and partner-to-HGS results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HGS→partner) and Y-score (partner→HGS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HIPK4 →	+0.055	+4.137	<.001	<.001	3	2
BLOOD_Leukemia	LYSMD1 →	+0.753	+2.489	.002	.007	3	2
BLOOD_Leukemia	BORCS6 →	+0.533	+2.489	.004	.007	3	2
OVARY	KRTAP19-8 →	+0.307	+4.807	<.001	.003	3	2
LARGE_INTESTINE	SH3GL2 →	+1.313	+3.474	<.001	.003	2	2
LARGE_INTESTINE	GALR3 →	+0.080	+3.646	.007	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 216 associations by consensus.

Exploration

HGS survival (RNA) · tumor vs normal (RNA) · all HGS data types