HGFAC

Across TCGA pan-cancer cohorts, HGFAC mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HGFAC data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher HGFAC mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HGFAC expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

LUAD, HNSC, and CCRCC are the cancer types where HGFAC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	III,IV	0.292	0.955	.001	35	view →
HNSC	DFS	Median	III,IV	0.881	0.695	.019	8	view →
CCRCC	DFS	Quartile	III,IV	0.730	0.270	.008	6	view →
LSCC	DFS	Median	II,III,IV	0.844	1.000	.010	4	view →
PDAC	OS	Quartile	III,IV	0.355	0.867	.010	4	view →
GBM	OS	Median	All	0.878	0.657	.019	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HGFAC–LUAD (DFS)

Open the LUAD breakdown →