HGFAC

Across TCGA patient cohorts, HGFAC mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HGFAC-associated genes across cancer lineages are 4E-BP1, TFRC, and Caspase-7-cleavedD198. Each is linked with HGFAC in more than 2 cancer types. Because this analysis shows association rather than direction, both HGFAC-to-partner and partner-to-HGFAC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by HGFAC-low versus HGFAC-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HGFAC→partner) and Y-score (partner→HGFAC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	4E-BP1 →	+0.371	+3.000	.008	.034	3	3
UCEC	TFRC →	+0.430	+2.999	.049	.035	3	2
STAD	Caspase-7-cleavedD198 →	+1.001	+3.321	.004	.010	1	3
COAD	14-3-3_epsilon →	+0.157	+2.849	.026	.034	3	1
UCEC	ACC1 →	+0.321	+1.807	.032	.027	3	1
UCEC	Rad50 →	-0.253	-3.584	.011	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

4E-BP1 by HGFAC expression — STAD

Explore this box plot interactively →