HGFAC

Across TCGA cell cohorts, HGFAC RNA expression is significantly associated with the go_rna of many other GO terms, with 2,694 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible HGFAC-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Negative regulation of syncytium formation by plasma membrane fusion, and Regulation of G1/S transition of mitotic cell cycle. Each is linked with HGFAC in more than 13 cancer types. Because this analysis shows association rather than direction, both HGFAC-to-partner and partner-to-HGFAC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by HGFAC-low versus HGFAC-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HGFAC→partner) and Y-score (partner→HGFAC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.188	+0.477	<.001	<.001	3	14
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.185	+0.477	<.001	<.001	3	14
BONE	Regulation of G1/S transition of mitotic cell cycle →	+0.058	+0.674	.006	.003	3	13
OESOPHAGUS	Positive regulation of double-strand break repair →	+0.085	+0.395	.001	.001	2	13
OESOPHAGUS	Regulation of RNA splicing →	+0.109	+0.460	<.001	<.001	3	12
BONE	Negative regulation of mRNA splicing, via spliceosome →	+0.112	+0.837	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,694 associations by consensus.

Negative regulation of myoblast fusion by HGFAC expression — OESOPHAGUS

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