HGFAC

Across TCGA cell cohorts, HGFAC mutation is significantly associated with the RNA expression of many other genes, with 411 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HGFAC-associated genes across cancer lineages are OTOR, HTN1, and TERB2. Each is linked with HGFAC in more than 1 cancer types. Because this analysis shows association rather than direction, both HGFAC-to-partner and partner-to-HGFAC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OTOR grouped by HGFAC-low versus HGFAC-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HGFAC→partner) and Y-score (partner→HGFAC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OTOR →	+0.022	+4.087	<.001	.009	3	1
URINARY_TRACT	HTN1 →	+0.197	+5.044	<.001	<.001	3	1
URINARY_TRACT	TERB2 →	+0.037	+4.087	<.001	.009	3	1
URINARY_TRACT	PRAMEF9 →	+0.010	+4.087	<.001	.009	3	1
URINARY_TRACT	PCDH11Y →	+0.012	+4.087	<.001	.009	3	1
BLOOD_Lymphoma	DMRTC2 →	+0.007	+4.058	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 411 associations by consensus.

OTOR by HGFAC expression — URINARY_TRACT

Explore this box plot interactively →