HGF

Across TCGA patient cohorts, HGF protein abundance is significantly associated with the RNA expression of many other genes, with 17,873 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HGF-associated genes across cancer lineages are IGF1, PRKG1, and ABCC9. Each is linked with HGF in more than 7 cancer types. Because this analysis shows association rather than direction, both HGF-to-partner and partner-to-HGF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HGF versus IGF1 in HNSC, with a Pearson correlation of 0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HGF→partner) and Y-score (partner→HGF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IGF1 →	+1.634	+2.009	<.001	.005	3	7
CCRCC	PRKG1 →	+0.993	+0.639	<.001	<.001	3	7
HNSC	ABCC9 →	+1.426	+1.973	.006	.004	2	8
CCRCC	C7 →	+2.076	+0.478	<.001	.002	3	7
LSCC	FGF7 →	+1.099	+0.434	<.001	<.001	3	7
CCRCC	PTGIR →	+1.062	+0.663	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,873 associations by consensus.

HGF vs IGF1 — HNSC

Explore this scatter interactively →