HGF

Across TCGA patient cohorts, HGF mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HGF-associated genes across cancer lineages are ASNS, c-Jun_pS73, and PCNA. Each is linked with HGF in more than 2 cancer types. Because this analysis shows association rather than direction, both HGF-to-partner and partner-to-HGF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by HGF-low versus HGF-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HGF→partner) and Y-score (partner→HGF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ASNS →	+0.367	+3.169	.045	.018	3	3
LUAD	c-Jun_pS73 →	-0.161	-2.983	.011	.034	3	3
LUSC	PCNA →	+0.177	+1.331	.016	.044	3	3
UCEC	MEK1 →	+0.359	+2.321	.002	<.001	3	3
UCEC	Cyclin-E2 →	+0.167	+1.935	.002	.002	3	3
UCEC	JNK2 →	+0.234	+1.716	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

ASNS by HGF expression — LUAD

Explore this box plot interactively →