HGD

Across TCGA patient cohorts, HGD RNA expression is significantly associated with the protein abundance of many other proteins, with 11,543 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HGD-associated proteins across cancer lineages are TTC39A, PIGR_S735, and PLEKHA6. Each is linked with HGD in more than 5 cancer types. Because this analysis shows association rather than direction, both HGD-to-partner and partner-to-HGD results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HGD versus TTC39A in BRCA, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HGD→partner) and Y-score (partner→HGD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TTC39A →	+0.883	+1.912	<.001	<.001	3	6
BRCA	PIGR_S735 →	+1.838	+1.667	.001	.005	3	5
LSCC	PLEKHA6 →	+0.693	+1.077	<.001	<.001	3	5
UCEC	RBM47 →	+0.501	+2.104	<.001	<.001	3	4
LSCC	TRIM29_S21 →	-1.248	-0.952	<.001	<.001	3	4
OV	PIGR →	+1.253	+1.387	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,543 associations by consensus.

HGD vs TTC39A — BRCA

Explore this scatter interactively →