HGD

Across TCGA patient cohorts, HGD mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HGD-associated genes across cancer lineages are eIF4E, ERK2, and GSK-3_pS9. Each is linked with HGD in more than 1 cancer types. Because this analysis shows association rather than direction, both HGD-to-partner and partner-to-HGD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by HGD-low versus HGD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HGD→partner) and Y-score (partner→HGD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.182	+3.459	.036	.005	2	2
UCEC	ERK2 →	+0.207	+1.807	.009	.027	3	1
UCEC	GSK-3_pS9 →	+0.329	+1.807	.048	.027	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.436	+2.125	.013	.010	3	1
UCEC	HER3_pY1289 →	-0.070	-2.302	.049	.034	3	1
UCEC	IGFBP2 →	-0.692	-1.807	.009	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

eIF4E by HGD expression — UCEC

Explore this box plot interactively →