HGD

Across TCGA cell cohorts, HGD RNA expression is significantly associated with the go_rna of many other GO terms, with 3,679 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible HGD-associated GO terms across cancer lineages are Sperm motility, Regulation of calcium ion import across plasma membrane, and Positive regulation of amino acid metabolic process. Each is linked with HGD in more than 7 cancer types. Because this analysis shows association rather than direction, both HGD-to-partner and partner-to-HGD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sperm motility grouped by HGD-low versus HGD-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HGD→partner) and Y-score (partner→HGD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Sperm motility →	-0.085	-2.419	<.001	<.001	3	8
PANCREAS	Regulation of calcium ion import across plasma membrane →	-0.128	-1.619	.001	<.001	3	8
KIDNEY	Positive regulation of amino acid metabolic process →	-0.275	-2.543	<.001	<.001	3	8
BREAST	Adenylate cyclase-activating serotonin receptor signaling pathway →	+0.211	+2.529	<.001	<.001	3	8
BREAST	Flagellated sperm motility →	-0.085	-2.419	<.001	<.001	3	8
LIVER	Nonribosomal peptide biosynthetic process →	+0.277	+4.564	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,679 associations by consensus.

Sperm motility by HGD expression — BREAST

Explore this box plot interactively →