HFM1

Across TCGA patient cohorts, HFM1 mutation is significantly associated with the total protein of many other genes, with 81 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HFM1-associated genes across cancer lineages are PAI-1, ASNS, and PCNA. Each is linked with HFM1 in more than 3 cancer types. Because this analysis shows association rather than direction, both HFM1-to-partner and partner-to-HFM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAI-1 grouped by HFM1-low versus HFM1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HFM1→partner) and Y-score (partner→HFM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PAI-1 →	+1.072	+3.321	.001	.010	3	4
LUAD	ASNS →	+0.746	+3.321	.001	.010	3	4
COAD	PCNA →	+0.216	+1.915	.016	.009	3	4
CESC	PI3K-p110-a →	-0.241	-3.000	<.001	.033	3	3
LUSC	ATM →	-0.556	-1.691	.003	.043	3	3
SKCM	N-Cadherin →	-0.175	-2.321	.029	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

PAI-1 by HFM1 expression — LUAD

Explore this box plot interactively →