HFM1

Across TCGA cell cohorts, HFM1 mutation is significantly associated with the RNA expression of many other genes, with 1,114 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HFM1-associated genes across cancer lineages are PLCL2, PDXP, and CHMP4B. Each is linked with HFM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HFM1-to-partner and partner-to-HFM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLCL2 grouped by HFM1-low versus HFM1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HFM1→partner) and Y-score (partner→HFM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PLCL2 →	+1.566	+3.070	<.001	.008	3	2
STOMACH	PDXP →	+0.908	+3.070	.006	.008	3	2
LARGE_INTESTINE	CHMP4B →	-0.535	-2.764	.003	.001	3	2
LARGE_INTESTINE	ACOT8 →	-0.531	-3.321	.003	.003	3	2
LARGE_INTESTINE	C1QBP →	+0.843	+2.936	<.001	<.001	3	2
LARGE_INTESTINE	TSPAN31 →	-0.606	-2.072	.003	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,114 associations by consensus.

PLCL2 by HFM1 expression — STOMACH

Explore this box plot interactively →