HFE

Across TCGA patient cohorts, HFE RNA expression is significantly associated with the protein abundance of many other proteins, with 13,430 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HFE-associated proteins across cancer lineages are PLS3, RNASEL, and VRK1. Each is linked with HFE in more than 5 cancer types. Because this analysis shows association rather than direction, both HFE-to-partner and partner-to-HFE results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HFE versus PLS3 in OV, with a Pearson correlation of 0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HFE→partner) and Y-score (partner→HFE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PLS3 →	+0.758	+0.713	.001	.004	3	5
OV	RNASEL →	+0.379	+0.826	<.001	.003	2	6
LSCC	VRK1 →	-0.374	-0.393	<.001	<.001	3	4
OV	WDR89 →	-0.289	-0.738	<.001	<.001	3	4
OV	CYC1 →	-0.656	-0.984	.001	<.001	3	4
GBM	FAM114A1 →	+0.463	+0.490	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,430 associations by consensus.

HFE vs PLS3 — OV

Explore this scatter interactively →