HFE

Across TCGA patient cohorts, HFE protein abundance is significantly associated with the RNA expression of many other genes, with 14,254 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HFE-associated genes across cancer lineages are FOLR2, RHOH, and CLEC2B. Each is linked with HFE in more than 3 cancer types. Because this analysis shows association rather than direction, both HFE-to-partner and partner-to-HFE results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HFE versus FOLR2 in OV, with a Pearson correlation of 0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HFE→partner) and Y-score (partner→HFE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FOLR2 →	+1.216	+0.599	.002	.001	3	4
GBM	RHOH →	+0.911	+0.564	<.001	<.001	3	4
OV	CLEC2B →	+0.909	+0.515	.009	.008	2	4
OV	ARHGAP9 →	+1.217	+0.840	<.001	.001	3	3
OV	IL2RA →	+1.118	+0.720	.001	.003	3	3
GBM	MYO1G →	+0.959	+0.585	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,254 associations by consensus.

HFE vs FOLR2 — OV

Explore this scatter interactively →