HFE

Across TCGA patient cohorts, HFE mutation is significantly associated with the RNA expression of many other genes, with 2,834 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HFE-associated genes across cancer lineages are RN7SL575P, MIR16-2, and EXOGP1. Each is linked with HFE in more than 2 cancer types. Because this analysis shows association rather than direction, both HFE-to-partner and partner-to-HFE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL575P grouped by HFE-low versus HFE-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HFE→partner) and Y-score (partner→HFE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL575P →	+0.082	+3.302	.004	.009	3	3
LGG	MIR16-2 →	+0.363	+7.977	<.001	.007	3	2
BRCA	EXOGP1 →	+0.041	+4.883	.001	.006	3	2
BRCA	MIR582 →	+0.396	+4.683	<.001	.007	3	2
COAD	RNU6ATAC30P →	+0.480	+4.893	<.001	.005	3	2
COAD	MIR1262 →	+0.685	+4.516	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,834 associations by consensus.

RN7SL575P by HFE expression — SKCM

Explore this box plot interactively →