HFE

Across TCGA patient cohorts, HFE mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HFE-associated genes across cancer lineages are YAP, EGFR_pY1068, and EGFR. Each is linked with HFE in more than 1 cancer types. Because this analysis shows association rather than direction, both HFE-to-partner and partner-to-HFE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YAP grouped by HFE-low versus HFE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HFE→partner) and Y-score (partner→HFE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	YAP →	+0.155	+2.817	.003	.001	3	2
UCEC	EGFR_pY1068 →	-0.256	-2.222	.003	.010	3	1
UCEC	EGFR →	-0.238	-3.674	<.001	.001	3	1
UCEC	eIF4E →	+0.201	+2.713	.006	.003	3	1
UCEC	FoxM1 →	+0.210	+1.662	.021	.011	3	1
UCEC	FOXO3a_pS318_S321 →	-0.106	-2.222	.016	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

YAP by HFE expression — UCEC

Explore this box plot interactively →