HFE

Across TCGA cell cohorts, HFE RNA expression is significantly associated with the go_rna of many other GO terms, with 4,633 significant associations in total. CNS shows the largest number of these associations.

The most reproducible HFE-associated GO terms across cancer lineages are Negative regulation of antigen processing and presentation of peptide antigen, Xenophagy, and Regulation of antigen processing and presentation of peptide antigen. Each is linked with HFE in more than 13 cancer types. Because this analysis shows association rather than direction, both HFE-to-partner and partner-to-HFE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of antigen processing and presentation of peptide antigen grouped by HFE-low versus HFE-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HFE→partner) and Y-score (partner→HFE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of antigen processing and presentation of peptide antigen →	+1.307	+2.174	<.001	<.001	3	14
LUNG_SCLC	Xenophagy →	+0.262	+1.730	<.001	<.001	3	13
BONE	Regulation of antigen processing and presentation of peptide antigen →	+1.197	+1.062	<.001	<.001	3	12
BREAST	Regulation of iron ion transport →	-0.209	-1.587	<.001	.002	2	13
SOFT_TISSUE	Cellular response to iron ion →	-0.186	-1.686	<.001	<.001	3	10
SOFT_TISSUE	Antigen processing and presentation of exogenous peptide antigen via MHC class Ib →	+0.286	+1.809	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,633 associations by consensus.

Negative regulation of antigen processing and presentation of peptide antigen by HFE expression — SOFT_TISSUE

Explore this box plot interactively →