HFE

Across TCGA cell cohorts, HFE mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. OESOPHAGUS shows the largest number of these associations.

The most reproducible HFE-associated genes across cancer lineages are NLRP8, KLHL34, and PPIAL4F. Each is linked with HFE in more than 1 cancer types. Because this analysis shows association rather than direction, both HFE-to-partner and partner-to-HFE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NLRP8 grouped by HFE-low versus HFE-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HFE→partner) and Y-score (partner→HFE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	NLRP8 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	KLHL34 →	+0.013	+4.906	<.001	.006	3	1
OESOPHAGUS	PPIAL4F →	+0.060	+4.906	<.001	.006	3	1
BLOOD_Leukemia	OR51T1 →	+0.071	+4.922	<.001	.009	3	1
BLOOD_Leukemia	GSG1L2 →	+0.058	+5.969	<.001	.001	3	1
LARGE_INTESTINE	ACER1 →	+0.072	+4.145	.006	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

NLRP8 by HFE expression — OESOPHAGUS

Explore this box plot interactively →