HEYL

Across TCGA cell cohorts, HEYL RNA expression is significantly associated with the go_rna of many other GO terms, with 3,712 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible HEYL-associated GO terms across cancer lineages are Heterochromatin formation, RNA splicing, via transesterification reactions, and Epigenetic regulation of gene expression. Each is linked with HEYL in more than 13 cancer types. Because this analysis shows association rather than direction, both HEYL-to-partner and partner-to-HEYL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heterochromatin formation grouped by HEYL-low versus HEYL-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HEYL→partner) and Y-score (partner→HEYL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Heterochromatin formation →	+0.076	+1.003	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	RNA splicing, via transesterification reactions →	+0.081	+0.691	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Epigenetic regulation of gene expression →	+0.059	+0.901	.005	.002	3	14
LUNG_NSCLC_LUSC	Negative regulation of gene expression, epigenetic →	+0.061	+0.768	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Heterochromatin organization →	+0.069	+1.003	<.001	<.001	3	14
OESOPHAGUS	Establishment of protein localization to organelle →	+0.067	+1.358	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,712 associations by consensus.

Heterochromatin formation by HEYL expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →