HEY2

Across TCGA patient cohorts, HEY2 mutation is significantly associated with the RNA expression of many other genes, with 3,121 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HEY2-associated genes across cancer lineages are TRAV34, RPL12P3, and MRPS21P1. Each is linked with HEY2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HEY2-to-partner and partner-to-HEY2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAV34 grouped by HEY2-low versus HEY2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEY2→partner) and Y-score (partner→HEY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAV34 →	+0.215	+1.645	.004	.003	3	2
COAD	RPL12P3 →	+0.185	+4.721	<.001	.004	3	2
COAD	MRPS21P1 →	+0.352	+4.285	.001	<.001	3	2
UCEC	RN7SKP12 →	+0.159	+2.414	<.001	.003	3	2
BLCA	RNU6-1040P →	+0.328	+7.640	<.001	.009	3	2
LUAD	LINC01702 →	+0.413	+4.191	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,121 associations by consensus.

TRAV34 by HEY2 expression — UCEC

Explore this box plot interactively →