HEY1

Across TCGA pan-cancer cohorts, HEY1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HEY1 data layer compared with 24 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher HEY1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HEY1 expression acts as an unfavorable survival marker.

LGG, UCEC, and COAD are the cancer types where HEY1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.208	0.896	<.001	12	view →
UCEC	OS	Median	II,III,IV	0.566	0.854	.001	10	view →
COAD	OS	Median	III,IV	0.168	0.691	.041	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

HEY1–LGG (OS)

Open the LGG breakdown →