Across TCGA patient cohorts, HEXIM1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HEXIM1-associated genes across cancer lineages are p21, PRAS40_pT246, and ASNS. Each is linked with HEXIM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HEXIM1-to-partner and partner-to-HEXIM1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEXIM1→partner) and Y-score (partner→HEXIM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p21 →	+0.205	+3.087	.007	<.001	3	2
UCEC	PRAS40_pT246 →	+0.202	+2.459	.003	.019	3	2
UCEC	ASNS →	+0.313	+1.700	.031	.042	3	2
UCEC	14-3-3_beta →	-0.107	-2.295	.007	.033	3	1
UCEC	EGFR_pY1068 →	-0.247	-2.584	.014	.010	3	1
UCEC	FoxM1 →	+0.307	+2.415	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration

HEXIM1 survival (RNA) · tumor vs normal (RNA) · all HEXIM1 data types