Across TCGA patient cohorts, HEXA RNA expression is significantly associated with the protein abundance of many other proteins, with 10,008 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible HEXA-associated proteins across cancer lineages are TBC1D2B, CD276, and CSK. Each is linked with HEXA in more than 5 cancer types. Because this analysis shows association rather than direction, both HEXA-to-partner and partner-to-HEXA results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HEXA→partner) and Y-score (partner→HEXA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TBC1D2B →	+0.336	+0.339	.003	<.001	3	6
LSCC	CD276 →	+0.414	+0.356	<.001	<.001	3	5
GBM	CSK →	+0.236	+0.267	.003	.007	3	5
LSCC	VPS41 →	+0.188	+0.362	.001	<.001	3	5
OV	PTPN9 →	+0.274	+0.421	<.001	.005	3	5
GBM	FCGRT →	+0.501	+0.358	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,008 associations by consensus.

Exploration

HEXA survival (RNA) · tumor vs normal (RNA) · all HEXA data types