Across TCGA patient cohorts, HEXA protein abundance is significantly associated with the RNA expression of many other genes, with 14,905 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HEXA-associated genes across cancer lineages are CSE1L, SPC25, and AURKB. Each is linked with HEXA in more than 4 cancer types. Because this analysis shows association rather than direction, both HEXA-to-partner and partner-to-HEXA results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEXA→partner) and Y-score (partner→HEXA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CSE1L →	-0.518	-0.355	<.001	<.001	3	5
LUAD	SPC25 →	-0.797	-0.353	<.001	<.001	3	5
BRCA	AURKB →	-0.794	-0.214	<.001	<.001	3	5
UCEC	KIF18B →	-0.882	-0.384	.002	<.001	3	5
BRCA	TPX2 →	-0.862	-0.261	<.001	<.001	3	5
GBM	SFRP2 →	+1.388	+0.295	.002	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,905 associations by consensus.

Exploration

HEXA survival (RNA) · tumor vs normal (RNA) · all HEXA data types