Across TCGA patient cohorts, HEXA mutation is significantly associated with the RNA expression of many other genes, with 3,430 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HEXA-associated genes across cancer lineages are TMEM251, AASDH, and GART. Each is linked with HEXA in more than 1 cancer types. Because this analysis shows association rather than direction, both HEXA-to-partner and partner-to-HEXA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEXA→partner) and Y-score (partner→HEXA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TMEM251 →	+0.561	+2.828	<.001	.001	3	2
UCEC	AASDH →	+0.501	+2.375	<.001	<.001	3	2
UCEC	GART →	+0.691	+2.332	<.001	<.001	3	2
UCEC	RFT1 →	+0.372	+1.947	.002	.003	3	2
UCEC	CCNDBP1 →	+0.506	+2.815	<.001	.001	3	2
UCEC	MRPL13 →	+0.508	+3.754	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,430 associations by consensus.

Exploration

HEXA survival (RNA) · tumor vs normal (RNA) · all HEXA data types