Across TCGA patient cohorts, HEXA mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HEXA-associated genes across cancer lineages are C-Raf, GAPDH, and Shc_pY317. Each is linked with HEXA in more than 2 cancer types. Because this analysis shows association rather than direction, both HEXA-to-partner and partner-to-HEXA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEXA→partner) and Y-score (partner→HEXA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.164	+3.584	.002	.002	3	3
UCEC	GAPDH →	+0.555	+2.662	.005	<.001	3	2
UCEC	Shc_pY317 →	-0.157	-1.906	.005	.015	3	2
UCEC	ATM →	-0.539	-3.571	.001	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.920	+2.169	<.001	.003	3	2
UCEC	14-3-3_beta →	-0.081	-2.973	.031	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

HEXA survival (RNA) · tumor vs normal (RNA) · all HEXA data types