Across TCGA cell cohorts, HES5 RNA expression is significantly associated with the go_rna of many other GO terms, with 760 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible HES5-associated GO terms across cancer lineages are Prostaglandin secretion, Response to glucocorticoid, and Negative regulation of canonical Wnt signaling pathway. Each is linked with HES5 in more than 5 cancer types. Because this analysis shows association rather than direction, both HES5-to-partner and partner-to-HES5 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HES5→partner) and Y-score (partner→HES5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Prostaglandin secretion →	-0.843	-0.100	.001	.003	2	6
UPPER_AERODIGESTIVE_TRACT	Response to glucocorticoid →	+0.067	+0.535	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	Negative regulation of canonical Wnt signaling pathway →	+0.058	+0.441	<.001	.003	3	4
UPPER_AERODIGESTIVE_TRACT	Cellular response to antibiotic →	+0.143	+0.562	<.001	<.001	3	3
LUNG_NSCLC_LUSC	Regulation of phosphatidylcholine biosynthetic process →	-0.193	-0.101	.002	.008	3	3
LUNG_NSCLC_LUSC	Positive regulation of phosphatidylcholine biosynthetic process →	-0.193	-0.101	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 760 associations by consensus.

Exploration

HES5 survival (RNA) · tumor vs normal (RNA) · all HES5 data types